Kisspeptin is a family of neuropeptides encoded by the KISS1 gene, primarily studied in endocrinology, neurobiology, and reproductive biology. It plays a key role in regulating the hypothalamic–pituitary–gonadal (HPG) axis through activation of the KISS1 receptor (GPR54) in experimental systems.

What It Is

Kisspeptin is a bioactive signaling peptide derived from a larger precursor protein. Multiple active forms exist, including Kisspeptin-54, Kisspeptin-14, Kisspeptin-13, and Kisspeptin-10, with Kisspeptin-10 commonly used in laboratory research due to its short sequence and receptor activity.

Chemical & Structural Properties

• Peptide class: Neuropeptide
• Common research form: Kisspeptin-10
• Sequence (Kisspeptin-10): Tyr–Asn–Trp–Asn–Ser–Phe–Gly–Leu–Arg–Phe–NH₂
• Form: Lyophilized powder
• Quantity: 10 mg per vial
• Purity: ≥99% (research-grade)

Biological Role (Research Context)

Kisspeptin is investigated in experimental systems for:

• Activation of KISS1R (GPR54) signaling pathways
• Regulation of gonadotropin-releasing hormone (GnRH) neurons
• Neuroendocrine control of reproductive signaling
• Hormonal feedback mechanisms
• Cell signaling and regulatory pathway studies

Mechanistic Areas of Study

Research commonly focuses on:

• GnRH secretion and downstream hormone signaling (in vitro / animal models)
• Endocrine system regulation and feedback loops
• Receptor binding and signaling dynamics
• Puberty and reproductive system modeling in experimental settings
• Cancer biology (metastasis suppression pathways)

Laboratory & Research Applications

Used in controlled research environments for:

• Endocrine and reproductive biology studies
• Neuroscience and hypothalamic signaling research
• Cell culture and receptor-binding assays
• Animal model experimentation
• Peptide–receptor interaction analysis

Handling & Storage (Research Settings)

• Store at −20°C or lower
• Protect from light, heat, and moisture
• Reconstitute using sterile laboratory-grade solvents or buffers
• Avoid repeated freeze–thaw cycles
• Maintain aseptic laboratory procedures

Important Notice

This product contains 10 mg of Kisspeptin and is intended for research purposes only.
It is not for human consumption.