MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondria-derived peptide (MDP) encoded within the mitochondrial 12S rRNA gene. It is widely studied in molecular biology, metabolism research, and mitochondrial science for its role in cellular energy regulation and stress response signaling.

What It Is

MOTS-c is a short bioactive peptide (16 amino acids) produced from mitochondrial DNA rather than nuclear DNA. It functions as a signaling molecule that can influence communication between the mitochondria and the nucleus in experimental systems.

Chemical & Structural Properties

• Peptide length: 16 amino acids
• Sequence: Met–Arg–Trp–Gln–Glu–Met–Gly–Ile–Phe–Tyr–Pro–Arg–Lys–Leu–Arg
• Form: Lyophilized powder
• Quantity: 10 mg per vial
• Purity: ≥99% (research-grade)

Biological Role (Research Context)

MOTS-c is investigated in experimental models for:

• Regulation of cellular metabolism
• Mitochondrial-to-nuclear signaling pathways
• Cellular stress response and adaptation
• Energy homeostasis and AMPK pathway involvement
• Metabolic function in cell and animal models

Mechanistic Areas of Study

Research commonly focuses on:

• AMPK activation and metabolic signaling
• Glucose metabolism and nutrient utilization
• Oxidative stress and mitochondrial function
• Gene expression under metabolic stress conditions
• Exercise-related metabolic signaling pathways

Laboratory & Research Applications

Used in controlled research environments for:

• Cell culture experiments
• Mitochondrial and metabolic studies
• Biochemical and molecular assays
• Peptide signaling research
• Experimental model development

Handling & Storage (Research Settings)

• Store at −20°C or lower
• Protect from light, heat, and moisture
• Reconstitute using sterile laboratory-grade solvents or buffers
• Avoid repeated freeze–thaw cycles
• Maintain aseptic laboratory procedures

Important Notice

This product contains 10 mg of MOTS-c and is intended strictly for research purposes only.
It is not for human consumption.